Prof. Elizabeth Vierling

My research interests are primarily in processes that occur post-transcriptionally and post-translationally to regulate cell function. A major component of our research program is aimed at understanding the mechanism of action and biological roles of molecular chaperones. Molecular chaperones are a structurally diverse group of highly conserved proteins that share the capacity to bind substrate proteins that are in non-native states. This interaction can facilitate proper protein folding and maturation, protein targeting and dissolution of protein aggregates formed due to stress or disease, giving chaperones a broad impact on normal cell function and stress responses. We have focused on the structure and function of the small heat shock proteins and the HSP100 class of chaperones. In addition, we have an expanding program investigating factors other than chaperones that are essential for organismal stress tolerance, including new work on an enzyme involved in nitric oxide (NO) metabolism, and efforts to understand translational regulation during stress. In striving to address basic biological questions, our research extends from biochemical and protein structural studies to molecular and classical genetic analysis. Our current studies utilize Arabidopsis thaliana and the cyanobacterium Synechocystis sp. PCC6803 as model organisms.
Type
party
Access Privileges
Division of Plant Science
Title
Prof.
Given Name
Elizabeth
Surname
Vierling
ORCID
https://orcid.org/0000-0002-0066-4881
Brief Description
My research interests are primarily in processes that occur post-transcriptionally and post-translationally to regulate cell function.
Full Description
My research interests are primarily in processes that occur post-transcriptionally and post-translationally to regulate cell function. A major component of our research program is aimed at understanding the mechanism of action and biological roles of molecular chaperones. Molecular chaperones are a structurally diverse group of highly conserved proteins that share the capacity to bind substrate proteins that are in non-native states. This interaction can facilitate proper protein folding and maturation, protein targeting and dissolution of protein aggregates formed due to stress or disease, giving chaperones a broad impact on normal cell function and stress responses. We have focused on the structure and function of the small heat shock proteins and the HSP100 class of chaperones. In addition, we have an expanding program investigating factors other than chaperones that are essential for organismal stress tolerance, including new work on an enzyme involved in nitric oxide (NO) metabolism, and efforts to understand translational regulation during stress. In striving to address basic biological questions, our research extends from biochemical and protein structural studies to molecular and classical genetic analysis. Our current studies utilize Arabidopsis thaliana and the cyanobacterium Synechocystis sp. PCC6803 as model organisms.
Email Address
vierling@biochem.umass.edu
Website Address
https://www.umass.edu/biochemistry-molecular-biology/faculty/elizabeth-vierling
Fields of Research
3108 - Plant biology; 310802 - Plant biochemistry ; 310806 - Plant physiology
Socio-Economic Objective
269901 - Climate adaptive plants
Status: Published
Published to:
  • Australian National University
  • Australian National Data Service
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