Response dynamics of rat barrel cortex neurons to repeated sensory stimulation

TypeCollection
TitleResponse dynamics of rat barrel cortex neurons to repeated sensory stimulation
Collection TypeRepository
Access PrivilegesMedicine & Health Sciences
DOI - Digital Object Identifier10.4225/13/59a5f73786ca7
Metadata LanguageEnglish
Data LanguageEnglish
Brief DescriptionThese files include the raw electrophysiological and immunofluorescent imaging data obtained from rat cortex. The results from these data determine the response dynamics of rat barrel cortex neurons.
Full DescriptionNeuronal adaptation is a common feature observed at various stages of sensory processing. In this article, we quantified the time course of adaptation in rat somatosensory cortex. Under urethane anesthesia, we juxta-cellularly recorded single neurons (n=147) while applying a series of whisker deflections at various frequencies (2-32 Hz). For ~90% of neurons, the response per unit of time decreased with frequency. The degree of adaptation increased along the train of deflections and was strongest at the highest frequency. However, a subset of neurons showed facilitation producing higher responses to subsequent deflections. The response latency to consecutive deflections increased both for neurons that exhibited adaptation and for those that exhibited response facilitation. Histological reconstruction of neurons (n=45) did not reveal a systematic relationship between adaptation profiles and cell types. In addition to the periodic stimuli, we applied a temporally irregular train of deflections with a mean frequency of 8Hz. For 70% of neurons, the response to the irregular stimulus was greater than that of the 8Hz regular. This increased response to irregular stimulation was positively correlated with the degree of adaptation. Altogether, our findings demonstrate high levels of diversity among cortical neurons, with a proportion of neurons showing facilitation at specific temporal intervals.
Contact Emailehsan.arabzadeh@anu.edu.au
ehsan.kheradpezhouh@anu.edu.au
Contact Phone Number+61 (2) 61254349
+61 (2) 61254353
Contact Fax Number+61 (2) 61252687
Principal InvestigatorEhsan Kheradpezhouh, Ehsan Arabzadeh
SupervisorsEhsan Arabzadeh
Fields of Research1109 - Neurosciences
KeywordsRaw data
Type of Research ActivityPure basic research
Date Coverage
Date FromDate To
20142016
Date of data creation2016
Year of data publication2017
Creator(s) for Citation
Given NameSurname
EhsanKheradpezhouh
EhsanArabzadeh
Publisher for CitationScientific Reports Journal
Access Rights TypeOpen
Retention Periodindefiitely
Extent or Quantity13
Data Size30.4GB
Status: Published
Published To:
- Australian National University
Identifier: anudc:5522
Files

Estimates:

  • Files: 13
  • Size: 30.4 GB

Data Files

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