Response dynamics of rat barrel cortex neurons to repeated sensory stimulation

Neuronal adaptation is a common feature observed at various stages of sensory processing. In this article, we quantified the time course of adaptation in rat somatosensory cortex. Under urethane anesthesia, we juxta-cellularly recorded single neurons (n=147) while applying a series of whisker deflections at various frequencies (2-32 Hz). For ~90% of neurons, the response per unit of time decreased with frequency. The degree of adaptation increased along the train of deflections and was strongest at the highest frequency. However, a subset of neurons showed facilitation producing higher responses to subsequent deflections. The response latency to consecutive deflections increased both for neurons that exhibited adaptation and for those that exhibited response facilitation. Histological reconstruction of neurons (n=45) did not reveal a systematic relationship between adaptation profiles and cell types. In addition to the periodic stimuli, we applied a temporally irregular train of deflections with a mean frequency of 8Hz. For 70% of neurons, the response to the irregular stimulus was greater than that of the 8Hz regular. This increased response to irregular stimulation was positively correlated with the degree of adaptation. Altogether, our findings demonstrate high levels of diversity among cortical neurons, with a proportion of neurons showing facilitation at specific temporal intervals.
Type
Collection
Title
Response dynamics of rat barrel cortex neurons to repeated sensory stimulation
Collection Type
Repository
Access Privileges
Medicine & Health Sciences
DOI - Digital Object Identifier
10.4225/13/59a5f73786ca7
Metadata Language
English
Data Language
English
Brief Description
These files include the raw electrophysiological and immunofluorescent imaging data obtained from rat cortex. The results from these data determine the response dynamics of rat barrel cortex neurons.
Full Description
Neuronal adaptation is a common feature observed at various stages of sensory processing. In this article, we quantified the time course of adaptation in rat somatosensory cortex. Under urethane anesthesia, we juxta-cellularly recorded single neurons (n=147) while applying a series of whisker deflections at various frequencies (2-32 Hz). For ~90% of neurons, the response per unit of time decreased with frequency. The degree of adaptation increased along the train of deflections and was strongest at the highest frequency. However, a subset of neurons showed facilitation producing higher responses to subsequent deflections. The response latency to consecutive deflections increased both for neurons that exhibited adaptation and for those that exhibited response facilitation. Histological reconstruction of neurons (n=45) did not reveal a systematic relationship between adaptation profiles and cell types. In addition to the periodic stimuli, we applied a temporally irregular train of deflections with a mean frequency of 8Hz. For 70% of neurons, the response to the irregular stimulus was greater than that of the 8Hz regular. This increased response to irregular stimulation was positively correlated with the degree of adaptation. Altogether, our findings demonstrate high levels of diversity among cortical neurons, with a proportion of neurons showing facilitation at specific temporal intervals.
Contact Email
ehsan.arabzadeh@anu.edu.au; ehsan.kheradpezhouh@anu.edu.au
Contact Phone Number
+61 (2) 61254349; +61 (2) 61254353
Contact Fax Number
+61 (2) 61252687
Principal Investigator
Ehsan Kheradpezhouh, Ehsan Arabzadeh
Supervisors
Ehsan Arabzadeh
Fields of Research
1109 - Neurosciences
Keywords
Raw data
Type of Research Activity
Pure basic research
Date Coverage
2014
2016
Date of data creation
2016
Year of data publication
2017
Creator(s) for Citation
Ehsan
Kheradpezhouh
Ehsan
Arabzadeh
Publisher for Citation
Scientific Reports Journal
Access Rights Type
Open
Retention Period
indefiitely
Extent or Quantity
13
Data Size
30.4GB
Status: Published
Published to:
  • Australian National University
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